The next door neighbors Nell Bedworth and Woody Deane have opposite behaviors and hate each other: the virgin geek Nell is polite, sensitive and well-prepared to go to Yale, while Woody is rude and his greatest expectation is to join a mediocre university due to his abilities playing football. When Nell and Woody are assigned to visit a museum together, they argue in front of a statue of an Aztec god. During the night, their souls swap bodies, bringing difficult situations to them. They first try to damage each others reputation in high school, but soon they discover that their dream of joining college can only happen with mutual respect and support.

Tim Callahan, aide to New York Senator Lauren Platt, is disappointed that all of the $3 million funding has been pulled from his latest pet project, a safe zone for children and youth. His personal partner, private investigator Donald Strachey, believes Tim's passion for the project stems from the fact of his own sister's troubled youth, she who has been missing since age seventeen. Tim believes his prayers have been answered when a man, identifying himself as a lawyer, tells him that he represents someone who wants to make a $3 million anonymous donation to the project. Those prayers turn into a nightmare when that lawyer is later found murdered, the dead body in Donald's car. The murdered man is Jake Lenigan, a third generation lawyer in a powerful family law firm. Jake's father was murdered twelve years earlier, the perceived suspect in that case being his wife Joan...